The Iowa State Cyclones football team will play a 12-game regular season schedule in 2025, including six home games at Jack Trice Stadium in Ames, Iowa. The Cyclones will open the season on September 6th at home against the Northern Iowa Panthers. They will then travel to face the Iowa Hawkeyes in the annual Cy-Hawk Trophy game on September 13th.
The rest of Iowa State’s 2025 schedule includes home games against the Kansas Jayhawks, the Oklahoma Sooners, the Texas Tech Red Raiders, and the West Virginia Mountaineers. The Cyclones will also travel to face the Baylor Bears, the Kansas State Wildcats, the Oklahoma State Cowboys, and the TCU Horned Frogs.